Endocrine Abstracts

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary autosomal dominant tumor syndrome caused by inactivating mutations of the tumor suppressor gene MEN1 which encodes the protein menin. It is characterized by the occurrence of tumors involving two or more endocrine glands, primarily parathyroid, entero-pancreatic, and anterior pituitary, as well as non-endocrine neoplasms. Glucagonomas occur in fewer than 3% of patients with MEN1, causing hyper...

Purpose: Obesity is a chronic disease with a high risk of cardiovascular and metabolic comorbidities, hence a decrease > 5-10% of the initial body weight (BW) is essential to achieve improvement of cardiometabolic dysfunction. Bariatric surgery currently represents a valid therapeutic option in this clinical setting, especially in patients unresponsive to a dietary-nutritional approach. Obesity instigates adaptive hormone changes, yet the role of baseline hormone setting o...

Background: The incidence of type 2 Diabetes Mellitus (T2D) is increasing worldwide. Prevention is possible by changing lifestyle but it’s not effective alone in real life, due to poor compliance over time. New strategies are necessary, mostly for high-risk individuals. Therapeutic microbiology is a further proposed target, and butyrate-producing bacteria can improve metabolic parameters in obese patients. Our study aims to evaluate the effect of Intestinimonas butyri...